Angela's possession becomes worse she taunts her psychiatrist, Dr. A distraught Roger confesses that Angela's mother was a prostitute she is pregnant just a few months after Roger met her but abandoned the baby at birth leaving Angela to be raised by Roger. Lozano sends her to a psychiatric hospital. However, Angela begins to show symptoms of demonic possession when she almost drowns a baby, followed by forcing a detective to commit suicide. Just as her life support is about to be switched off, she comes round, seemingly in perfect health. A few days later, she is released, but in the taxi on the way home, she violently grabs the wheel, causing an accident that puts her in a coma for 40 days. She is injected with a serum that causes an infection at home, she experiences a seizure and is placed under care at a hospital. She accidentally cuts herself and is rushed to the hospital, where she briefly meets Father Lozano ( Michael Peña). Two months earlier in the United States, Angela is given a surprise birthday party by her father, Roger ( Dougray Scott), and boyfriend, Peter "Pete" Smith ( John Patrick Amedori).
In the Vatican, Vicar Imani ( Djimon Hounsou) shows Cardinal Bruun ( Peter Andersson) the case of Angela Holmes ( Olivia Taylor Dudley), a young American woman who is suspected of harboring an evil spirit.